Designing the Biocompatibility of Biohybrids - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 285

Designing the Biocompatibility
of Biohybrids

Frank Witte, Ivonne Bartsch and Elmar Willbold

Abstract Biohybrid has been used as a fashionable term in scientific publications
during the past years to describe a functional unit consisting of a bioactive and a
structural component. The bioactive part of the biohybrid could consist of cells or
bioactive molecules, while the structural part is of biological or non-biological
origin. Biohybrids are currently used as implants and transplants in regenerative
medicine or in vitro applications such as assays, biosensors or bioreactors.
However, a clear definition of a biohybrid has not been given yet. This chapter
reviews the current applications of biohybrids and identifies the challenges of
biohybrids in in vivo applications. A classification of biohybrids according to their
functional use and application is provided.

Keywords Artificial organs Biocompatibility Biohybrid Biomaterial Drug
delivery Tissue engineering

Contents

1 Introduction........................................................................................................................ 286

2 Compatibility of the Structural Compound ...................................................................... 287

3 Compatibility of the Bioactive Compound ...................................................................... 288

4 Classification of Biohybrids.............................................................................................. 289

4.1 Classification of Biohybrids According to Their Function..................................... 290

4.2 Classification of Biohybrids According to Their Therapeutical Application ........ 291

5 General Advantages and Limitations of Biohybrids........................................................ 293

6 Conclusions........................................................................................................................ 293

References ............................................................................................................................... 293

F. Witte ( ) I. Bartsch E. Willbold

Laboratory for Biomechanics and Biomaterials, Orthopaedic Clinic,
Hannover Medical School, Anna-von-Borries-Strabe 1-7,
30625 Hannover, Germany
e-mail: [e-mail]
F. Witte I. Bartsch E. Willbold
Center for Biocompatibility and Implant-Immunology, CrossBIT,
Hannover Medical School, Feodor-Lynen-Strabe 31,
30625 Hannover, Germany

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