The Cell–Surface Interaction - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 13

(a)

Cell number results for fibroblasts cultured on TAN

150000

100000

50000

0

1 5 10

Time (days)

TAN-EP TAN-S SS

(b)

Cell number results for RC cells cultured on TAN

200000

150000

100000

50000

0

02468041

Time (days)

TAN-EP TAN-PP TAN-S SS

Fig. 1 Differences in cytocompatibility of surfaces. a Fibroblasts cultured on electropolished and
standard titanium-6% aluminium-7% niobium (TAN) for 1, 5 and 10 days. The beta-phase particles
of the standard TAN surface are shown to disrupt the cytoskeleton (blue arrows) and this was
associated with a decrease in cell number. However, polishing of the surface negates this effect and
cells can proliferate [ 59 ]. b Rat calvaria osteoblasts cultured on standard, electropolished and paste-
polished TAN. Although similar disruption is observed to the cytoskeleton as on standard TAN (white
arrows), this was not observed to influence osteoblast proliferation [ 71 ]. TAN-EP electropolished
TAN, TAN-PP paste-polished TAN, TAN-S standard microrough TAN, SS Stainless steel