Biomedical Engineering Reference
In-Depth Information
controlled sequential delivery. Novel biomaterials such as affinity-binding alginate
may serve as a platform for such devices. The utilization of such controllable
biomaterials may also enable the creation of innovative complex hierarchical
matrices for the potential regeneration of organized tissues such as the osteo-
chondral tissue. New synthetic small molecules with regulatory functions, as well
as new synthetic polymers for control over stem cell fate decisions, are yet to be
found, possibly via high-throughput screening technologies. Moreover, the design
and application of ''smart'' bioreactors will facilitate better understanding of the
dynamic nature of stem cell microenvironment, and subsequently precise control
over biochemical and physical signals for stem cell fate decisions. Finally, scale-
up technologies will be needed for realizing stem cell potential in clinical research.
To conclude, given the complexity of stem cell fate control, much has still to be
learned, yet our growing knowledge has already made major breakthroughs in
manipulating stem cell fate, raising more high expectations from future research.
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