Bioactive Glass-Based Scaffolds for Bone Tissue Engineering - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 195

Bioactive Glass-Based Scaffolds for Bone
Tissue Engineering

Julia Will, Lutz-Christian Gerhardt and Aldo R. Boccaccini

Abstract Originally developed to fill and restore bone defects, bioactive glasses
are currently also being intensively investigated for bone tissue engineering
applications. In this chapter, we review and discuss current knowledge on porous
bone tissue engineering scaffolds made from bioactive silicate glasses. A brief
historical review and the fundamental requirements in the field of bone tissue
engineering scaffolds will be presented, followed by a detailed overview of recent
developments in bioactive glass-based scaffolds. In addition, the effects of ionic
dissolution products of bioactive glasses on osteogenesis and angiogenic properties
of scaffolds are briefly addressed. Finally, promising areas of future research and
requirements for the advancement of the field are highlighted and discussed.

Keywords Bioactive glasses Scaffolds Bone tissue engineering Angiogenesis

Contents

1 Introduction........................................................................................................................ 196

2 Scaffold Requirements ...................................................................................................... 199

3 Bioactive Glass Processing ............................................................................................... 200

4 Bioactive Glass-Ceramic Scaffolds.................................................................................. 202

4.1 Fabrication and Microstructures............................................................................... 202

4.2 Mechanical Properties .............................................................................................. 204

4.3 In-Vitro and In-Vivo Studies ................................................................................... 208

5 Bioactive Glass Containing Composite Scaffolds............................................................ 208

6 Effect of Bioactive Glass on Angiogenesis...................................................................... 213

7 Conclusions and Future Work .......................................................................................... 215

References................................................................................................................................ 217

J. Will A. R. Boccaccini ( )

Department of Materials Science and Engineering,
Institute of Biomaterials, University of Erlangen-Nuremberg,
Cauerstr. 6, 91058 Erlangen, Germany
e-mail: [e-mail]
L.-C. Gerhardt
Biomedical Engineering, Soft Tissue Biomechanics and Engineering,
Technische Universiteit Eindhoven, PO Box 513, 5600 MB,
Eindhoven, The Netherlands

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