The Cell–Surface Interaction - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 1

The Cell-Surface Interaction

J. S. Hayes, E. M. Czekanska and R. G. Richards

Abstract The realm of surface-dependent cell and tissue responses is the
foundation of orthopaedic-device-related research. However, to design materials
that elicit specific responses from tissues is a complex proposition mainly because
the vast majority of the biological principles controlling the interaction of cells
with implants remain largely ambiguous. Nevertheless, many surface properties,
such as chemistry and topography, can be manipulated in an effort to selectively
control the cell-material interaction. On the basis of this information there has
been much research in this area, including studies focusing on the structure and
composition of the implant interface, optimization of biological and chemical
coatings and elucidation of the mechanisms involved in the subsequent
cell-material interactions. Although a wealth of information has emerged, it
also advocates the complexity and dynamism of the cell-material interaction.
Therefore, this chapter aims to provide the reader with an introduction to the basic
concepts of the cell-material interaction and to provide an insight into the factors
involved in determining the cell and tissue response to specific surface features,
with specific emphasis on surface microtopography.

Keywords Mechanotransduction Microroughness Surface topography

Tissue-implant interface

Abbreviations

APC Anodic-plasma-chemical

BMP Bone morphogenetic protein

CaP Calcium phosphate

CoCrMo Cobalt-chromium-molybdenum

ECM Extracellular matrix

EPSS Electropolished stainless steel

ERK Extracellular-signal-regulated kinase

FAK Focal adhesion kinase

J. S. Hayes ( )

Regenerative Medicine Institute, National Centre for Biomedical Engineering Science,
National University of Ireland, Galway, Republic of Ireland
e-mail: [e-mail]
E. M. Czekanska R. G. Richards
AO Research Institute, Davos, Switzerland

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