Interaction of Cells with Decellularized Biological Materials - Tissue Engineering: Cell-Surface Interactions for Tissue Culture - page 105

Interaction of Cells with Decellularized
Biological Materials

Mathias Wilhelmi, Bettina Giere and Michael Harder

Abstract The idea to create the concept of cardiovascular ''tissue engineering'' is
based on the recognition that until then all known allogeneic/xenogeneic biolog-
ical or alloplastic implant materials were associated with shortcomings, which led
to graft deterioration, degradation and finally destruction. Thus, it aims to develop
viable cardiovascular structures, e.g. heart valves, myocardium or blood vessels,
which ideally demonstrate mechanisms of remodeling and self-repair, a high
microbiological resistance, complete immunological integrity and a functional
endothelial cell layer to guarantee physiological hemostasis. In our current review
we aim to identify basic limitations of previous concepts, explain why the use of
decellularized matrices was a logical consequence and which limitations still exist.

Bioartificial organs Extracellular matrix Tissue engineering

Keywords

Contents

1 Introduction........................................................................................................................ 106

2 Native Grafts ..................................................................................................................... 106

3 Decellularized Grafts......................................................................................................... 108

4 Reseeding Concepts........................................................................................................... 109

5 Spontaneous In Situ Autologization ................................................................................. 110

6 Immunogenicity of Extracellular Matrices....................................................................... 112

7 Conclusion ......................................................................................................................... 113

References ............................................................................................................................... 114

M. Wilhelmi ( )

Division of Cardiac, Thoracic, Transplantation and Vascular Surgery,
Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1,
30625 Hannover, Germany
e-mail: [e-mail]
B. Giere M. Harder
corlife GbR, Feodor-Lynen-Str. 23,
30625 Hannover, Germany

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