Biomimetic Synthesis of Self-Assembled Mineralized Collagen-Based Composites for Bone Tissue Engineering - Biomimetics: Advancing Nanobiomaterials and Tissue Engineering - page 45

between these two grafts is not the hierarchical structure but the bioactive
components. Therefore, when it comes to the fabrication of composites
mimicking natural bone for bone defect repair, functional biomimetics
should be paid more attention along with the componential and structural
biomimetics.
Besides, the unique assemblies of organic/inorganic hybrids are ubiqui-
tous in many natural calcifi ed tissues. Many features of biomineralization
processes present in bone are also found in other systems. A better under-
standing of the structure, formation, and dissolution of such organic/min-
erals units in mineralized collagen will lead to improve the understanding
on the formations of other calcifi ed tissues. This knowledge will also be
helpful in the treatment of widespread pathological calcifi cations, such
as atherosclerosis, stone formation, or dental calculus. Further progress
in the topic of mineralized collagen materials can be expected to come
from modern genetics, where gene structures are now known to control
the dynamic self-assembly of both cellular and protein processes.

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