Design and Synthesis of Photoreactive Polymers for Biomedical Applications - Biomimetics: Advancing Nanobiomaterials and Tissue Engineering - page 249

11
Design and Synthesis of Photoreactive
Polymers for Biomedical Applications
Ponnurengam Malliappan Sivakumar 1 , Di Zhou 1 ,
Tae Il Son 2 and Yoshihiro Ito 1, *
1 Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute,
Saitama, Japan
2 Department of Biotechnology, Chung-Ang University,
Anseong, Republic of Korea
Abstract
Photoreactive polymers are useful for biological and medical applications. In this
chapter we will describe the preparation of ultraviolet or visible light-curable bio-
logical polymer derivatives or synthetic polymers and review our applications for
micropatterning surfaces, microarray chips, or biosealants.
Keywords: Photoreactivity, photoimmobilization, photolithography, micropat-
terning, bio-nonfouling, photocrosslinking, gelatin, polysaccharide, biosealant,
and bioadhesive
11.1 Introduction
Various types of photoreactive or photoresponsive polymers have been
developed for chemical and medical applications. Here, we discuss some
photoreactive biopolymers designed for medical applications. One group
comprises ultraviolet (UV) light-reactive biopolymers, including biologi-
cal macromolecules such as gelatin, hyaluronic acid, chitosan, pullulan,
and synthetic polymers such as stimuli-responsive polymers and bio-non-
fouling polymers. Another group comprises visible light-reactive polymer
systems. The former are utilized for surface micropatterning for cell cul-
ture and preparing microarray chips. The latter are used as biosealants or
bioadhesives. These are summarized in Figure 11.1.