Hydroxyapatite-Biodegradable Polymer Nanocomposite Microspheres Toward Injectable Cell Scaffold - Biomimetics: Advancing Nanobiomaterials and Tissue Engineering - page 218

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Hydroxyapatite-Biodegradable
Polymer Nanocomposite
Microspheres Toward Injectable Cell
Scaffold
Syuji Fujii 1, *, Masahiro Okada 2 and Tsutomu Furuzono 3
1 Department of Applied Chemistry, Faculty of Engineering, Osaka Institute
of Technology, Osaka, Japan
2 Department of Biomaterials, Osaka Dental University, Osaka, Japan
3 Department of Biomedical Engineering, School of Biology-Oriented Science
and Technology, Kinki University, Wakayama, Japan
Abstract
Hydroxyapatite (HAp)-biodegradable polymer hybrid microspheres have
attracted great interest in both academic and industrial areas, because there
is a wide range of potential applications especially in the biomedical fi eld.
Hybridization of HAp with biodegradable polymer is important for improvement
of cell adhesion properties. Usually, hybrid microspheres are fabricated using
molecular-level surfactants, which are suspected of causing allergy-like reactions
and carcinogenicity. Strategies for the fabrication of HAp-biodegradable polymer
hybrid microspheres without the use of such molecular-level surfactants should be
developed.
We have developed a facile and versatile “surfactant-free” fabrication method
of HAp-biodegradable polymer nanocopmosite microspheres: nanosized HAp
particles were employed as a particulate stabilizer in order to prevent fl occula-
tion of microspheres as well as to improve cell adhesion properties of the biode-
gradable polymer. It has been confi rmed that the nanocomposite microspheres
can work as an effective injectable scaffold, which enhances cell-based therapeutic
angiogenesis with bone marrow mononuclear cells.
Keywords: Microspheres, Pickering emulsion, nanocomposite, hydroxyapatite,
biodegradable polymer, injectable scaffold