Biomimetic Nanofi brous Scaffolds for Bone Tissue Engineering Applications - Biomimetics: Advancing Nanobiomaterials and Tissue Engineering - page 84

in polymers capable of forming nanofi bers and control over exact fi ber
diameter and orientation remains a challenge. Overall, the processing
challenges associated with each appear surmountable, and refi nements to
fabrication technique should reduce or eliminate many of these concerns.
The potential to increase the effi cacy of tissue engineering scaffolds by
incorporating nanofi brous surface features appears vast. In nearly every
instance, any type of nanofi brous scaffold has been shown to be equal
or superior to similar scaffolds without nanoscale surface features, even
though few studies have attempted to optimize nanofi ber properties to
achieve a specifi c cellular behavior. Further investigation in the form of a
systematic look at the effects of nanofi ber size, orientation, and composi-
tion on cellular behavior, and a better understanding of the cellular mecha-
nisms that respond to nanofi brous surfaces should allow the creation of
scaffolds far more effective at controlling and accelerating cellular behavior.
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