Biomedical Engineering Reference
In-Depth Information
Fig. 27.2
Long-term simulation of the catabolic effect of PTH treatment combined with cyclic
mechanical loading in a murine caudal vertebra
short-term prediction of the effects of hormone depletion due to ovariectomy, cyclic
loading, and pharmaceutical treatments with anabolic (parathyroid hormone (PTH)),
and anti-resorptive (bisphosphonate (BIS)) agents, as well as for the control studies
for all groups. The model is also capable of long-term prediction (Fig.
27.2
). The
input micro-CT images of the murine caudal vertebra were obtained from a con-
comitant
in vivo
study. The results of both
in silico
and
in vivo
study have been
assessed qualitatively as described elsewhere (Schulte,
2011
). For the quantitative
evaluation, both static and dynamic morphometric parameters were calculated, and
comparative physiome maps were constructed for each parameter showing again
strong agreement between experiment and simulation.
27.4 Organ Level
Due to their place in the hierarchy of bone modeling, organ-level simulations often
treat bone as a continuum, disregarding local architecture, and biological events. In-
stead, such models focus on global stresses and strains, as well as on the interaction
