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et al., 2011 ), and that changes in mechanical loading can directly affect cell prolif-
eration rates (Desmond et al., 2005 ). Lastly, we note that the biomechanical events
that cause folding anomalies associated with pathological conditions warrant further
attention.
Acknowledgements We gratefully acknowledge funding support from NIH grants R01
GM075200 and R01 NS070918 (LAT), as well as a fellowship for BAF from NIH T90 DA022871
and the Mallinckrodt Institute of Radiology, Washington University.
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