Biomedical Engineering Reference
In-Depth Information
in addition, may form an integral part of a study addressing the direction of allevi-
ating the symptoms of hydrocephalus when considering the aforementioned cases
of atresia in the fourth ventricle. This model also allows for the natural incorpo-
ration of further, multiscalar detail by involving cellular level interactions such as
aquaporin-centered transport, believed to facilitate rapid absorption from CSF and
ISF.
The functional implications of the interthalamic adhesion (IA) and how it in-
fluences the CSF dynamics remains unclear. In the build-up to the current work,
it was witnessed that varying the position of the IA varied the flow characteristics
and pressure distribution quite considerably. Some very preliminary work has been
carried out to link the IA with Chiari malformations (Cheng et al.,
2010
), and an
appreciation of its imposing characteristics could prove pivotal when considering
the pulsatile distribution of CSF within the ventricles during systole and diastole.
Acknowledgements
This study is supported by the Digital Economy Programme; a Research
Councils UK cross-Council initiative led by EPSRC and contributed to by AHRC, ESRC, and
MRC. The EPSRC is further acknowledged for providing the resources necessary for the High
Performance Computing simulations conducted in this study. The ESI Group and Dr. M. Megahed
are kindly acknowledged for allowing the use of the CFD-ACE+ multiphysics suite.
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