Biomedical Engineering Reference
In-Depth Information
Chapter 8
Multiscale Skeletal Muscle Modeling:
From Cellular Level to a Multi-segment Skeletal
Muscle Model of the Upper Limb
Oliver Röhrle, Michael Sprenger, Ellankavi Ramasamy, and Thomas Heidlauf
Abstract
Modeling the biomechanical behavior of the musculoskeletal system re-
quires a multiscale modeling approach spanning several length and time scales.
Within this paper, two skeletal muscle models are presented. The first model is an
electromechanical skeletal muscle model that couples neurophysiological recruit-
ment principles and electrochemical processes of a sarcomere to the mechanical
behavior of a single skeletal muscle through a multiscale continuum-mechanical
constitutive law. The second model combines principles of multi-body dynamics
and principles of continuum mechanics and the finite element method to achieve the
first three-dimensional forward-dynamics model of a musculoskeletal system. Both
muscle models can be coupled together in future research to obtain an overall skele-
tal muscle model spanning from cellular processes to a musculoskeletal system.
O. Röhrle
T. Heidlauf
Cluster of Excellence for Simulation Technology, University of Stuttgart, Pfaffenwaldring 5a,
70569 Stuttgart, Germany
·
M. Sprenger
·
O. Röhrle (
·
·
T. Heidlauf
Institute of Applied Mechanics (CE), University of Stuttgart, Pfaffenwaldring 7, 70569 Stuttgart,
Germany
e-mail:
roehrle@mechbau.uni-stuttgart.de
M. Sprenger
T. Heidlauf
)
M. Sprenger
O. Röhrle
·
E. Ramasamy
Fraunhofer Institute for Manufacturing Engineering and Automation IPA, Nobelstr. 12, 70569
Stuttgart, Germany
E. Ramasamy
