Biomedical Engineering Reference
In-Depth Information
Figure 2.2-11 Plasma insulin.
Figure 2.2-9 Parameters for the source block labelled insulin
concentration in
Fig. 2.2-8
.
shorter than the simulation, the ''From Workspace'' block
provides the ability to specify what to do for the missing
data. These source sampling parameters are specified in
the block parameters, shown in
Fig. 2.2-9
.
where the data is the MATLAB variable It, the sample
time is 5 (meaning 5 minutes), the missing data is in-
terpolated, and the final value is held as the output after
the final data element.
Lastly, change the simulation parameters to start at 0.0
and end at 240.0 (minutes). The simulation output is
shown in the three scopes (
Figs. 2.2-10
-
2.2-12
).
In a GTT, the samples measured are compared to
a glucose profile that is similar to the simulation results
Figure 2.2-12 Interstitial insulin.
above. Notice that the glucose concentration dips below
the basal level at approximately one hour after the glu-
cose intake and subsequent insulin release. For this
simulation of normal conditions, the minimum glucose
concentration is 80 mg/dL.
In normal healthy adults, cognitive function is im-
paired when plasma glucose falls below 65 mg/dL. If the
plasma glucose dips below this level and the patient has
altered mood and/or impaired cognitive function, a di-
agnosis of reactive hypoglycemia is often made. If the
glucose level is normal, but the patient exhibits these
signs, then the condition is referred to as
postprandial
syndrome.
Figure 2.2-10 Glucose.
