Biomedical Engineering Reference
In-Depth Information
Fig. 3.2.16-3 Various methods for heparinization of surfaces: (A) heparin bound ionically on a positively charged surface; (B) heparin
ionically complexed to a cationic polymer, physically coated on a surface; (C) heparin physically coated and self-cross-linked on a surface;
(D) heparin covalently linked to a surface; (E) heparin covalently immobilized via spacer arms; (F) heparin dispersed into a
hydrophobic polymer; (G) heparin-albumin conjugate immobilized on a surface (
Kim and Feijen, 1985
).
Conclusions
biomolecules and cells on or within biomaterial supports.
Combined with the great variety of possible biomedical and
biotechnological applications, this represents a very exciting
and fertile field for applied research in biomaterials.
It can be seen that there is a wide and diverse range of
materials and methods available for immobilization of
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