Biomedical Engineering Reference
In-Depth Information
a standard, glass microscope slide in a 25
25 array.
Design a scheme to make such a proteomic chip.
What are the important surface issues? Which strat-
egies might you apply to address each of the issues?
You may find helpful ideas in Sections 3.1.4, 3.2.13,
and 3.2.16.
2.
A hydrogel surface must be put on a SR medical
device. A viscous solution of the hydrogel polymer is
used to spray-coat the device. When it is placed in
aqueous buffer solution the hydrogel layer quickly
delaminates from the silicone. How might you
permanently attach a hydrogel layer to a silicone
device? Briefly describe the method you would use
and the general steps needed to produce a reliable
coating.
3.
List the molecular and design factors that can con-
tribute to increasing the durability of an
n
-alkyl thiol
SAM on gold.
Bibliography
Archibald, D. D., Qadri, S. B., and Gaber,
B. P. (1996). Modified calcite deposition
due to ultrathin organic films on silicon
substrates.
Langmuir
12: 538-546.
Arkles, B. (1977). Tailoring surfaces with
silanes.
Chemtech
7: 766-778.
Bardos, D. I. (1990). Titanium and titanium
alloys in
Concise Encyclopedia of
Medical and Dental Materials,
1st ed.,
E. Williams, R. W. Cahn, and M. B.
Bever, eds. Pergamon Press, Oxford, pp.
360-365.
Bird, R. R., Hall, B., Hobbs, K. E. F., and
Chapman, D. (1989). New
haemocompatible polymers assessed by
thrombelastography.
J
.
Biomed. Eng.
11:
231-234.
Buchanan, R. A., Lee, I. S., and Williams, J.
M. (1990). Surface modification of
biomaterials through noble metal ion
implantation.
J. Biomed. Mater. Res.
24:
309-318.
Chapiro, A. (1983). Radiation grafting of
hydrogels to improve the thrombo-
resistance of polymers.
Eur. Polym. J.
19: 859-861.
Charlson, E. J., Charlson, E. M.,
Sharma, A. K., and Yasuda, H. K.
(1984). Electrical properties of
glow-discharge polymers, parylenes, and
composite films.
J. Appl. Polymer Sci.
Appl. Polymer Symp.
38: 137-148.
Chilkoti, A., Ratner, B. D., and Briggs, D.
(1991a). Plasma-deposited polymeric
films prepared from carbonyl-containing
volatile precursors: XPS chemical
derivatization and static SIMS surface
characterization.
Chem. Mater.
3:
51-61.
Chilkoti, A., Ratner, B. D., and Briggs, D.
(1991b). A static secondary ion mass
spectrometric investigation of the
surface structure of organic plasma-
deposited films prepared from stable
isotope-labeled precursors. Part I.
Carbonyl precursors.
Anal. Chem.
63:
1612-1620.
Chilkoti, A., Ratner, B. D., Briggs, D., and
Reich, F. (1992). Static secondary ion
mass spectrometry of organic plasma
deposited films created from stable
isotope-labeled precursors. Part II.
Mixtures of acetone and oxygen.
J.
Polymer Sci., Polymer Chem. Ed.
30:
1261-1278.
Cho, C. S., Takayama, T., Kunou, M., and
Akaike, T. (1990). Platelet adhesion
onto the Langmuir-Blodgett film of
poly-(gamma-benzyl
L
-glutamate)-
poly(ethylene oxide)-poly(gamma-
benzyl
L
-glutamate) block copolymer.
J.
Biomed. Mater. Res.
24: 1369-1375.
Chrisey, D. B., Piqu´, A., McGill, R. A.,
Horowitz, J. S., Ringeisen, B. R., Bubb,
D. M., and Wu, P. K. (2003). Laser
deposition of polymer and biomaterial
films.
Chem. Rev.
103: 553-576.
Chu, P. K., Chen, J. Y., Wang, L. P., and
Huang, N. (2002). Plasma surface
modification of biomaterials.
Mater. Sci.
Eng. Rep.
36: 143-206.
Colligon, J. S. (1986). Surface modification
by ion beams.
Vacuum
36: 413-418.
Dargaville, T. R., George, G. A.,
Hill, D. J. T., and Whittaker, A. K.
(2003). High energy radiation grafting of
fluoropolymers.
Prog. Polymer Sci.
28:
1355-1376.
Decher, G. (1996). Layered
nanoarchitectures via directed assembly
of anionic and cationic molecules. in
Comprehensive Supramolecular
Chemistry,
Vol. 9,
Templating, Self-
Assembly and Self-Organization,
J.-P.
Sauvage and M. W. Hosseini, eds.
Pergamon Press, Oxford, pp. 507-528.
Dekumbis, R. (1987). Surface treatment of
materials by lasers.
Chem. Eng. Prog.
83:
23-29.
Dunkirk, S. G., Gregg, S. L., Duran, L. W.,
Monfils, J. D., Haapala, J. E., Marcy, J.
A., Clapper, D. L., Amos, R. A., and
Guire, P. E. (1991). Photochemical
coatings for the prevention of bacterial
colonization.
J. Biomater. Appl.
131-156.
Everhart, D. S., and Reilley, C. N. (1981).
Chemical derivatization in electron
spectroscopy for chemical analysis of
surface functional groups introduced on
low-density polyethylene film.
Anal.
Chem.
53: 665-676.
Ferretti, S., Paynter, S., Russell, D. A., and
Sapsford, K. E. (2000). Self-assembled
monolayers: a versatile tool for the
formulation of bio-surfaces.
Trends
Anal. Chem.
19(9): 530-540.
Folch, A., and Toner, M. (2000).
Microengineering of cellular
interactions.
Ann. Rev. Bioeng.
2:
227-256.
Garbassi, F., Morra, M., Occhiello, E.,
Barino, L., and Scordamaglia, R. (1989).
Dynamics of macromolecules: A
challenge for surface analysis.
Surf.
Interface Anal.
14: 585-589.
Goessl, A., Garrison, M. D., Lhoest, J.,
and Hoffman, A. (2001). Plasma
lithography
thin-film patterning of
polymeric
þ
biomaterials by RF plasma
polymerization I: surface preparation
and analysis. J.
Biomater. Sci. Polymer
Ed.
12(7): 721-738.
Gombotz, W. R., and Hoffman, A. S.
(1988). Functionalization of polymeric
films by plasma polymerization of allyl
alcohol and allylamine.
J. Appl. Polymer
Sci. Appl. Polymer Symp.
42: 285-303.
Greer, R. T., Knoll, R. L., and Vale, B. H.
(1979). Evaluation of tissue-response to
hydrogel composite materials.
SEM
2:
871-878.
Griesser, H. J., and Chatelier, R
.
C. (1990).
Surface characterization of plasma
polymers from amine, amide and alcohol
monomers.
J. Appl. Polymer Sci. Appl.
Polymer Symp.
46: 361-384.
Gruner, H. (2001). Thermal spray coating
on titanium. in
Titanium in Medicine,
D.M. Brunette, P. Tengvall, M. Textor
and P. Thomsen, eds. Springer-Verlag,
Berlin.
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