RECENT ADVANCES IN FLOW CYTOMETRY: PLATFORMS, TOOLS, AND CHALLENGES FOR DATA ANALYSIS - Flow Cytometry in Drug Discovery and Development - page 25

TABLE 2.1 ( Continued )

Maximum Detection
Channels (Fluors/Scatter) Key Features

Main Application
Area Supplier Instrument Main Purpose Excitation Sources

Beckman Coulter Cell Lab Quanta

SC (with plate
loader option)

Cell analyzer 2 (488 nm þ arc

lamp)

3 þ Coulter
volume þ SSC

Absolute cell counts; HTS
with sample prep; sample
track and 21 CFR Pt 11

Clinical research and
drug discovery

Coulter EPICS
XL and
XL-MCL

Beckman Coulter Cell analyzer 1 (488 nm) 4 þ FSC þ SSC Digital processing; HTS

carousel option; single
laser simplicity

Clinical

Beckman Coulter Cytomics FC 500 Cell analyzer 2 (488, 635 nm) 5 þ FSC þ SSC Five-color detection off blue

line; digital compensation;
plate-based HTS option

Clinical

Beckman Coulter Gallios Cell analyzer 2 (blue and red) or 3

( þ violet)

6(5 þ 1), 8 (5 þ 3),
or 10 (5 þ 3 þ
2) þ FSC þ SSC

Optimized with reagents;
Boulevard light path; easy
change filters

Basic and clinical
research

Beckman Coulter MoFlo XDP Cell sorter 3 (from 355, 405,

488, 635 nm)

12 þ FSC þ SSC Multiple sort gates; four-way

sorting; 5 log dynamic
range

Basic and clinical
research

Beckman Coulter CyAn ADP Cell analyzer 2 (488, 642 nm) or 3

( þ 405 nm) laser
versions

7(5 þ 2) or
9(5 þ 2 þ 2)
þ FSC þ SSC

Benchtop footprint;
automated compensation;
walk-up operation

Basic and clinical
research

Beckman Coulter Navios Cell analyzer Awaiting data Awaiting data Awaiting data Awaiting data

iCyt/Sony Group Reflection Cell sorter 7 (from 355, 405,

488, 532, 561,
592, 640 nm)

Multiple PMTs and
FSC/SSC settings

Multiple sort streams; index or
proportional sorting;
highly flexible platform

Basic and clinical
research

Millipore Guava PCA Cell analyzer 1 (green) 2 FSC Compact benchtop; absolute

counting; microcapillary
flow cell

Basic and clinical
research

þ

Millipore Guava PCA-96

Base System

Cell analyzer 1 (green) 2 þ FSC Compact benchtop; auto-

mated MTP sampling;
microcapillary flow cell

Basic and clinical
research