Biomedical Engineering Reference
In-Depth Information
Murine System
Human System
Disease Populations
Drug Discovery
Preclinical and Clinical
Verification of
Immunological
characterization of
patients—
ex vivo
measurements
in populations and
case studies
Identification of
immunological
processes—
in vivo
and
in vitro
murine models
immunological
processes in human
system—
in vitro
cellular and
molecular methods
Biomarkers—
biological process,
disease processes,
therapeutic response
Target
identification
Target
validation
FIGURE 9.3
Translational medicine application in drug development. The development of new drug entities depends on the progression of scientific
advances from basic science laboratories to clinical research studies and to drug discovery laboratories. One examplewould be in the area of immunology
where discoveries made in the basic science laboratories are applied when characterizing immunological abnormalities in autoimmune populations. In
addition, the information would be used to identify new molecular targets for therapeutic intervention in the treatment of autoimmunity. Conversely,
biomarker results obtained during preclinical or clinical studies may assist in elucidating new immunological processes and feed information back to the
basic science laboratories.
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