CD4 T CELL ASSESSMENTS IN EVALUATION OF HIV THERAPEUTICS - Flow Cytometry in Drug Discovery and Development - page 180

safety of HIV therapeutics and in patient management to assess the efficacy of an ARV
drug regimen. As HIV therapeutics become more affordable and accessible to
patients, routine monitoring of CD4 T cells should be equally as accessible to
patients particularly in resource-limited settings where HIV infection is most pre-
valent. As new methods and instrumentation are developed for CD4 testing, it will be
increasingly important to evaluate these new approaches against previously estab-
lished methods. Correlation of methods should be evaluated in experiments involving
within-laboratory comparisons of instrumentation as well as good performance in
external quality assessment (EQA) programs. These measures will ensure that
whatever be the technique used to assess the CD4 þ T cells, the patient receives the
most appropriate and timely treatment.

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