Biomedical Engineering Reference
In-Depth Information
TABLE 8.2 Normal Human Blood Lymphocyte Subpopulations at Various Ages
Age Groups
Subpopulations (Cells/
m
L)
Cord Blood
2-3 Months
4-8 Months
12-23 Months
2-5 Years
7-17 Years
Adult
Total lymphocytes
Median (%)
5400 (41%)
5680 (66%)
5990 (64%)
5160 (59%)
4060 (50%)
2400 (40%)
2100 (32%)
Confidence intervals (%) 4200 (35%\)-
6900 (47%)
2920 (55%\)-
8840 (78%)
3610 (45%\)-
8840 (79%)
2180 (44%\)-
8270 (72%)
2400 (38%\)-
5810 (64%)
2000 (36%\)-
2700 (43%)
1600 (28%\)-
2400 (39%)
CD3 T cells
Median (%)
3100 (55%)
4030 (72%)
4270 (71%)
3300 (66%)
3040 (72%)
1800 (70%)
1600 (73%)
Confidence intervals (%) 2400 (49%\)-
3700 (62%)
2070 (55%\)-
6540 (78%)
2280 (45%\)-
6450 (79%)
1460 (53%\)-
5440 (81%)
1610 (62%\)-
4230 (80%)
1400 (66%\)-
2000 (76%)
960 (61%\)-
2600 (84%)
CD4 T cells
Median (%)
1900 (35%)
2830 (52%)
2950 (49%)
2070 (43%)
1800 (42%)
800 (37%)
940 (46%)
Confidence intervals (%) 1500 (28%\)-
2400 (42%)
1460 (41%\)-
5116 (64%)
1690 (36%\)-
4600 (61%)
1020 (31%\)-
3600 (54%)
900 (35%\)-
2860 (51%)
700 (33%\)-
1100 (41%)
540 (32%\)-
1660 (60%)
CD8 T cells
Median (%)
1500 (29%)
1410 (25%)
1450 (24%)
1320 (25%)
1180
800 (30%)
520 (27%)
Confidence intervals (%) 1200 (26%\)-
2000 (33%)
650 (16%\)-
2450 (35%)
720 (16%\)-
2490 (34%)
570 (16%\)-
2230 (38%)
630 (22%\)-
1910 (38%)
600 (27%\)-
900 (35%)
270 (13%\)-
930 (40%)
B cells (CD19 or CD20)
Median (%)
1000 (20%)
400 (16%)
246 (13%)
900 (23%)
900 (23%)
900 (23%)
900 (24%)
Confidence intervals (%) 200 (14%\)-
1500 (23%)
500 (19%\)-
1500 (31%)
500 (19%\)-
1500 (31%)
500 (19%\)-
1500 (31%)
700 (21%\)-
1300 (28%)
300 (12%\)-
500 (22%)
122 (10%\)-
632 (31%)
CD4:CD8 ratio
Median
1.2
2.2
2.1
1.6
1.4
1.3
1.7
Confidence intervals
0.8-1.8
1.3-3.5
1.2-3.5
1.0-3.0
1.0-2.1
1.1-1.4
0.9-4.5
Source: Stiehm ER, editor. Immunologic Disorders in Infants and Children, 4th ed., 1996.
Confidence intervals given are the 5th to 95th percentiles except where indicated (
); these are the 25th to 75th percentiles. B cells use the CD20 antigen except where indicated
(
); these use the CD19 antigen. The lymphocyte % is the percentage of total leukocytes. The CD3, CD4, CD8, and B cell (CD19 or CD20) % is the percentage of total
lymphocytes. Each subgroup contains at least 22 normal subjects. Combined data from Erkellor-Yuksel FM. et al. J. Pediatr. 1992;120:216-222 (cord blood, 7-17 years; B
cells); Denny T. et al. JAMA 1992;267:1484-1488 (2-3months to 5 years); Fahey JL, cited in Giorgi, JVet al. in Rose NR et al. Manual of Clinical Laboratory Immunology, 4th
ed., American Society for Microbiology, Washington, DC,1992, pp. 174-181 (adults).
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