Biomedical Engineering Reference
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FIGURE 5.11
(a) Cell cycle profiles of paired cell lines deficient of Topo II and the effects of
topoisomerase interacting drugs over two time point tests. See the resistance to etoposide of the
cell line in the box. (b) Cell cycle profiles of paired cell lines deficient of Topo I and the effects of
topoisomerase interacting drugs over two time point tests. See the resistance to camptothecin
and BMS-250749 on the drawn boxes. (c) Cell cycle profiles of paired cell lines deficient of p53
remained sensitive to topoisomerase interacting agents.
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