HTS FLOW CYTOMETRY, SMALL-MOLECULE DISCOVERY, AND THE NIH MOLECULAR LIBRARIES INITIATIVE - Flow Cytometry in Drug Discovery and Development - page 78

7 Multiplex screening for ABC transporter

inhibitors

1 R03MH07894601 R. Larson, UNM/I

Ivnitski-Steele, J. Strouse

2 200K, #1818

9 TR-FRET HTS assay for inhibitors of

MEKK2-MEK5 PB1 domain
interactions

1R03MH08483001 K. Nakamura, UNC/Z/Surviladze 3 300K, #1683

10 HTS for developing T Cell immune

modulators

1 X01MH08570701 I. Hwang, TSRI/M. Haynes, Y.

Wu

1 325 K, #2087

11 Chemical screen of TOR pathway GFP

fusion proteins in S. cerevisiae

1R03MH08645001 M. Werner-Washburne, UNM/J.

Chen, S. Young

5 325 K, #1908

11 A yeast HTS for caloric restriction mi-

metics that inhibit age-related
superoxide

1 R03MH08743901 W. Burhans, Roswell Park Cancer

Institute/C. Prudom, A. Jensen

1 325 K, in process

3 325K, in process 12 Identification of broad spectrum anti-

fungal efflux inhibitors

R03MH087406-01A1 R. Cannon, U. Otago/J. Strouse

1 330 K, in process Fast Track HTS for identification of VLA-4 allos-

teric modulators

1 R01HL08106201 L. Sklar, A. Chigaev UNM/P.

Simons, S. Young

13 RNA aptamer-based screen for selective

inhibitors of GRK2

1R03MH08937801
(approved)

J. Tesmer, U. Michigan/J. Chen 1 330 K, in process

R21 HTS to identify small molecules that

disrupt Rab GTPase activator and
effector protein interactions

1 R21NS06643501
(approved)

A. Wandinger-Ness, UNM/tbd tbd 330 K, projected