HTS FLOW CYTOMETRY, SMALL-MOLECULE DISCOVERY, AND THE NIH MOLECULAR LIBRARIES INITIATIVE - Flow Cytometry in Drug Discovery and Development - page 77

TABLE 4.3

#Targets compounds

screened, PubChem
summary AID#

Target Provider/UNM
Target Team Leader Cycle Title Award Mechanism

1 Primary HTS assay for formylpeptide

receptor (fpr) ligands and primary
HTS counter-screen assay for for-
mylpeptide-like-1 (FPRL1) ligands

X01MH07638101 B. Edwards, UNM/S. Young 2 25 K, #805, #1202

2 Disassembly of the 26S proteasome

(ATP hydrolysis dependent)

X01MH07761301 D. Skowyra, SLU/P. Simons 1 25 K, #1824

2 MLSCN assay for ligands of GPR30 and

classical estrogen receptors

X01MH07762701 E. Prossnitz, UNM/M. Dennis,

M. Haynes

3 640, #1989

2 MLSCNHTS assay for allosteric ligands

for the VLA-4 integrin

X01MH07763801 L. Sklar, UNM/A. Waller 2 25 K, #1998

1 25K, #1260

3 MLSCN assay for activators of prostate

cell differentiation

X01MH07893701 T. Thompson, UNM/M. Haynes

3 Bacterial quorum sensing inhibition as-

say for MLSCN 10 K and 17 K ST1
compound sets combined

X01MH07895201 P. Gresham, UNM/S. Young 1 25 K, #1206

4 HTS for Bcl-2 family multiplex X01MH07985001 L. Sklar, UNM, J. Reed,

BIMR/P. Simons

6 225 K, #1693

5 HTS to identify specific small-molecule

inhibitors of Ras and Ras-related
GTPases

X01MH08123101 A. Wandinger-Ness, UNM/Z.

Surviladze

6 225 K, #1772

R21 in lieu
of cycle 6

Multiplexed flow cytometry screens for
RGS inhibitors

1R21NS05701401 R. Neubig, U. Michigan/

Y. Wu, M. Haynes

5 225 K, #1504