Hardware Reference
In-Depth Information
The design procedure for a general-purpose microfluidic biochip is presented
in Chap. 6 . Section 6.1 describes previously published pin-assignment algorithms
and their limitations. Section 6.2 presents an analysis of pin-actuation conflicts,
and derives the necessary and sufficient conditions for control-pin sharing to
ensure high flexibility in the concurrent movement of two droplets. Section 6.3
introduces an integer linear programming model for designing a pin-assignment
with the smallest number of pins. Section 6.4 presents a graph-theoretic method
to formulate an acceptance test for a pin-assignment configuration and a lower
bound on the number of pins. A heuristic algorithm that generates a pin-assignment
configuration for biochips is proposed in Sect. 6.4 . Extension of the study from
1 volume droplets to 2 and even larger droplets is presented in Sect. 6.5 .
Section 6.6 presents the scheduling algorithm that can be applied to biochips
with pin-constraints. Simulation results for commercial biochips and experimental
prototypes are discussed in Sect. 6.7 . Finally, conclusions are drawn in Sect. 6.8 .
Based on the concepts discussed in Chaps. 2 - 4 and 6 , the concept of pin-limited
cyberphysical microfluidic biochip is proposed in Chap. 7 . The structure and layout
design of two-metal-layer biochips are introduced in Sect. 7.1 . In Sect. 7.2 the wire-
routing solution for general-purpose pin-limited biochips is proposed. The specific
design flow for pin-limited cyberphysical biochips is discussed in Sect. 7.3 . Results
for several experimental bioassays are discussed in Sect. 7.4 . Finally, conclusions
are drawn in Sect. 7.5 .
Chapter 8 summarizes the contributions of the topic.
References
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