Hardware Reference
In-Depth Information
Tabl e 7. 1 Synthesis results derived by the operation-interdependency-aware synthesis
approach on pin-limited biochips
Completion time (s)
Size of
Bioassay
the biochip
D/M phases
T phases
Tot al
Exponential dilution bioassay
8
8
116
181
297
9
9
59
163
222
10
8
67
161
228
12
8
54
244
298
Interpolation dilution bioassay
8
8
89
162
251
9 9
45
133
178
10
8
48
165
213
12
8
45
189
234
300
250
200
150
100
50
0
1
2
3
4
5
6
7
8
9
10
f T ( Hz )
PCR
Interpolating dilution of Protein
Exponential dilution of protein
Fig. 7.5 The relationship between completion time of bioassays and f T on ( a )an8 8 direct-
addressing biochip; ( b )the8 8 biochip shown in Fig. 7.4 a
7.4.2
Completion Time with Multiple Clock Frequencies
on Pin-Limited Biochip
In Sect. 4.5.4 we present the relationship between the bioassay completion time and
the clock frequency of the droplet transaction phase on a biochip with multiple
working frequencies. If the bioassays are executed on the 8 8 pin-limited electrode
array shown in Fig. 7.4 a, the relationship between completion time of bioassays and
the clock frequency of the T phase is shown in Fig. 7.5 . The execution times for
exponential dilution and interpolation dilution bioassays on the pin-limited biochip
can be greatly reduced by increasing f T . For example, when f T increases from 1 Hz
to 10 Hz, the execution time for exponential dilution bioassay is reduced from 297 s
to 134 s.
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