Hardware Reference
In-Depth Information
Tabl e 7. 1
Synthesis results derived by the operation-interdependency-aware synthesis
approach on pin-limited biochips
Completion time (s)
Size of
Bioassay
the biochip
D/M phases
T phases
Tot al
Exponential dilution bioassay
8
8
116
181
297
9
9
59
163
222
10
8
67
161
228
12
8
54
244
298
Interpolation dilution bioassay
8
8
89
162
251
9 9
45
133
178
10
8
48
165
213
12
8
45
189
234
300
250
200
150
100
50
0
1
2
3
4
5
6
7
8
9
10
f
T
(
Hz
)
PCR
Interpolating dilution of Protein
Exponential dilution of protein
Fig. 7.5
The relationship between completion time of bioassays and f
T
on (
a
)an8 8 direct-
addressing biochip; (
b
)the8 8 biochip shown in Fig.
7.4
a
7.4.2
Completion Time with Multiple Clock Frequencies
on Pin-Limited Biochip
In Sect.
4.5.4
we present the relationship between the bioassay completion time and
the clock frequency of the droplet transaction phase on a biochip with multiple
working frequencies. If the bioassays are executed on the 8
8 pin-limited electrode
array shown in Fig.
7.4
a, the relationship between completion time of bioassays and
the clock frequency of the T phase is shown in Fig.
7.5
. The execution times for
exponential dilution and interpolation dilution bioassays on the pin-limited biochip
can be greatly reduced by increasing f
T
. For example, when f
T
increases from 1 Hz
to 10 Hz, the execution time for exponential dilution bioassay is reduced from 297 s
to 134 s.