Hardware Reference
In-Depth Information
Tabl e 6. 3 The numbers of pins for the proposed pin-limited biochip,
bioassay-specific biochips [ 9 ], cross-referencing biochips [ 6 ], and
direct-addressing biochip
Multiplexed
Protein
bioassay
PCR
bioassay
No. Pins
No. Pins
No. Pins
Proposed heuristic method
19
19
18
Cross router [ 6 , 9 ]
30
30
30
Direct-addressing
59
62
52
Bioassay-specific [ 9 ]
25
14
27
ILP-based [ 18 ]
11
6
12
Tabl e 6. 4 Bioassay execution time on the proposed pin-
limited biochip, bioassay-specific biochips [ 9 ], cross-referencing
biochips [ 6 ], and direct-addressing biochip
Multiplexed
Protein
bioassay
PCR
bioassay
Time (s)
Time (s)
Time (s)
Proposed heuristic method
63
22
180
Cross router [ 6 , 9 ]
132
26
195
Direct-addressing
70
19
179
Bioassay-specific [ 9 ]
70
20
216
ILP-based [ 18 ]
73
19
161
pin-assignment configuration is determined. Therefore, the operation schedule
and routing pathways are more flexible, and they can be adjusted according to
the requirements of bioassays. Tables 6.3 and 6.4 show that the proposed method
can achieve fewer number of pins and shorter execution time, compared with
that cross-referencing biochips in [ 6 ]. The proposed general-purpose biochip can
greatly reduce the number of control pins with only a slight increase in the bioassay
completion time, compared with the direct-addressing biochips.
In order to compare the proposed method with the bioassay-specific biochips
in [ 9 ], we first derive the synthesis results of bioassays without considering
pin-assignment configurations. The initial synthesis results can be derived from
previously published synthesis tools in [ 21 - 23 ]. Then the operations schedules are
adjusted based on the signals applied to pins, as introduced in Sect. 6.6 .Tables 6.3
and 6.4 show that, the proposed method can achieve fewer number of control pins
and shorter execution time for multiplexed bioassay and protein dilution bioassay,
compared with the bioassay-specific biochips in [ 9 ].
In the following discussion, the multiplexed assay biochip, PCR bioassay
biochip, protein dilution biochip, and the multi-function biochip presented in
Fig. 6.18 are referred to as Chips 1 4; these four bioassay-specific biochips designed
 
Search WWH ::




Custom Search