Hardware Reference
In-Depth Information
Fig. 3.11
The sequencing graphs for two representative assays in flash chemistry: (
a
) synthesis of
unsymmetrical diarylethenes; (
b
) bromine-lithium exchange reaction of o-dibromobenzene [
33
]
3.9
Chapter Summary and Conclusions
In this chapter, we have described a dictionary-based hardware-assisted error
recovery approach for flash chemistry based on digital microfluidic biochips. The
proposed method minimizes the response time for error recovery, and provides
precise control of on-chip experiments for chemical synthesis. The proposed error-
recovery procedure and dynamic re-synthesis of a reaction can be implemented in
real-time on an FPGA. In order to store the error dictionary in the limited memory
available in the FPGA, we have presented two compaction techniques for reducing
the size of the error dictionary. We have used five laboratorial protocols to show that,
compared to software-based methods, the proposed dictionary-based error-recovery
method has negligible impact on the time-to response. It also requires less complex
experimental setup, and needs only a small amount of memory on the FPGA board.
