Threat by chemical substances: Legislation, production, use and waste - Environmental Deterioration and Contamination: Problems and their Management - page 59

The relation between deterioration in reproductive potential and the exposure
to industrial chemicals, e.g., in workplaces has been investigated from the 1980s
and found correlation between testicular function and certain chemicals such as
dibromochloropropane, a soil fumigant and nematocide on crops that was widely
used agriculturally until the 1980s (ATSDR, 1992; IRIS, 1999), or chloroprene, the
monomer for the production of the polymer polychloroprene, a type of synthetic rub-
ber (NIOSH, 2010). After the first evidences on reprotoxicity of certain industrial
chemicals, reprotoxicity became a priority hazard and, together with carcinogenicity
and mutagenicity, special attention has been paid to it.
Reprotoxic substances are listed below (not a complete list) based on a Dutch
investigation (Muller & Bos, 2004):

- 1-(2-Chloroethyl)-3-cyclohexyl- - Clobetasol propionate

1-nitrosourea - Clomiphene citrate

- 2-Bromo-2-chloro-1,1,1-trifluoroethane - Clorazepatedipotassium

- Acetazolamide - Cocaine

- Acetohydroxamic acid - Codeine phosphate

- Acetylsalicylic acid - Cycloate

- Actinomycin D - Cyclophosphamide

- Adriamycin - Cyclophosphamide (hydrated)

- Alprazolam - Cytarabine

- Amantadine hydrochloride - Dacarbazine

- Amikacin sulfate - Danazol

- Aminoglutethimide - Daunorubicinhydrochloride

- Aminopterin - DES

- Amiodarone hydrochloride - Diazepam

- Amoxapine, angiotensin converting - Diazoxide

enzyme (ace) inhibitors - Dichlorphenamide

- Anisindione - Diflunisal

- Atenolol - Dihydroergotaminemesylate

- Auranofin - Diisopropyl mercury

- Beclomethasonedipropionate - Diltiazem hydrochloride

- Benzphetamine hydrochloride - Dioxin (2,3,7,8-tetrachlorodibenzo-

- Biphenyl, hexabromo-bis(isobutyl) p-dioxin or tcdd)

mercury - Disodium cyanodithioimidocarbonate

- Bischloroethylnitrosourea (BCNU) - Doxycycline

- Bromacil lithium salt - Doxycycline calcium (internal use)

- Butabarbital sodium - Doxycycline hyclate (internal use)

- Carbamazepine - Doxycycline monohydrate (internal use)

- Carboplatin - Ergotamine tartrate

- Chenodiol - Etodolac

- Chlorcyclizine hydrochloride - Etoposide

- Chlordiazepoxide - Etretinate

- Chlordiazepoxide hydrochloride - Filgrastim

- Cidofovir - Firemaster bp-6

- Cladribine - Firemaster ff-1

- Clarithromycin - Flunisolide