Chemistry Reference
In-Depth Information
Me
R
Me
Me
H
O
N
H
N
N
N
Me
Sn
II
Me
N
N
N
N
O
Na
O
O
O
NaO
2
C
n
hematoporphyrin derivative
n = 1-4, Photofrin®
tin ethyl etiopurpurin
Puryltin
tm
OH
N
OOO
OMe
NH
N
N
N
Lu
III
N
OOO
OMe
N
HN
N
OH
tetraphenylchlorin
Foscan®
metoxifin lutetium
Lutex
O
NH
3
+
Cl
-
O
OH
5-aminolevulinic acid
Levulan®
Figure 8.1
Chemical structures of compounds in clinical use and clinical trial for PDT in the
United States
15
etiopurpurin (Puryltin™) , and mono-L-aspartyl chlorine, with Lutex and Puryltin™
being the only inorganic centred chromophores in clinical trial.
15
8.1.3 Characteristics of PDT Agents
Ideal PDT agents absorb light strongly in the red or near-infrared (NIR) region of
the spectrum, accumulate within the target tissue, effi ciently perform the intended
