Chemistry Reference
In-Depth Information
32.
Gu , J. ; Spitz , M.R. ; Zhao , H. ; Lin , J. ; Grossman , H.B. ; Dinney , C.P.
et al.
; Roles of tumor
suppressor and telomere maintenance genes in cancer and aging - an epidemiological
study ;
Carcinogenesis
, 2005 ,
26
( 10 ), 1741 - 1747 .
Biroccio , A. ; Rizzo , A. ; Elli , R. ; Koering , C.E. ; Belleville , A. ; Benassi , B.
et al.
; TRF2
inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells;
Eur.
J. Cancer
, 2006 ,
42
( 12 ), 1881 - 1888 .
Colgin , L.M. ; Baran , K. ; Baumann , P. ; Cech , T.R. ; Reddel , R.R. ; Human POT1 facilitates
telomere elongation by telomerase;
Curr. Biol.
, 2003 ,
13
( 11 ), 942 - 946 .
Hockemeyer , D. ; Palm , W. ; Else , T. ; Daniels , J.P. ; Takai , K.K. ; Ye , J.Z.
et al.
; Telomere
protection by mammalian Pot1 requires interaction with Tpp1;
Nat. Struct. Mol. Biol.
,
2007 ,
14
( 8 ), 754 - 761 .
Etheridge , K.T. ; Compton , S.A. ; Barrientos , K.S. ; Ozgur , S. ; Griffi th , J.D. ; Counter , C.M. ;
Tethering telomeric double- and single-stranded DNA binding proteins inhibits tel-
omere elongation;
J. Biol. Chem.
, 2008 ,
283
( 11 ), 6935 - 6941 .
W a n g , F. ; Podell , E.R. ; Zaug , A.J. ; Yang , Y. ; Baciu , P. ; Cech , T.R.
et al.
; The POT1 - TPP1
telomere complex is a telomerase processivity factor;
Nature
,
33.
34.
35.
36.
37.
2007 ,
445
( 7127 ),
506 - 510 .
Xin , H. ; Liu , D. ; Wan , M. ; Safari , A. ; Kim , H. ; Sun , W.
et al.
; TPP1 is a homologue of
ciliate TEBP -beta and interacts with POT1 to recruit telomerase;
Nature
, 2007 ,
445
( 7127 ),
559 - 562 .
Blasco , M.A.; Telomeres and human disease: ageing, cancer and beyond;
Nat. Rev. Genet.
,
2005 ,
6
( 8 ), 611 - 622 .
Hockemeyer , D. ; Sfeir , A.J. ; Shay , J.W. ; Wright , W.E. ;
38.
39.
40.
de Lange , T. ; POT1 protects telom-
eres from a transient DNA damage response and determines how human chromosomes
end ;
EMBO J.
, 2005 ,
24
( 14 ), 2667 - 2678 .
Celli , G.B. ; de Lange , T. ; DNA processing is not required for ATM - mediated telomere
damage response after TRF2 deletion;
Nat. Cell Biol.
, 2005 ,
7
( 7 ), 712 - 718 .
Zhu , X.D. ; Niedernhofer , L. ; Kuster , B. ; Mann , M. ; Hoeijmakers , J.H. ; de Lange , T. ;
ERCC1/XPF removes the 3′ overhang from uncapped telomeres and represses forma-
tion of telomeric DNA-containing double minute chromosomes;
Mol. Cell
, 2003 ,
12
( 6 ),
1489 - 1498 .
Wu , L. ; Multani , A.S. ; He , H. ; Cosme - Blanco , W. ; Deng , Y. ; Deng , J.M.
et al.
; Pot1 defi -
ciency initiates DNA damage checkpoint activation and aberrant homologous recom-
bination at telomeres;
Cell
, 2006 ,
126
( 1 ), 49 - 62 .
He , H. ; Multani , A.S. ; Cosme - Blanco , W. ; Tahara , H. ; Ma , J. ; Pathak , S.
et al.
; POT1b
protects telomeres from end-to-end chromosomal fusions and aberrant homologous
recombination ;
EMBO J.
, 2006 ,
25
( 21 ), 5180 - 5190 .
Greider , C.W. ; Blackburn , E.H. ; Identifi cation of a specifi c telomere terminal transferase
activity in
Tetrahymena
extracts ;
Cell
, 1985 ,
43
( 2 Pt 1 ), 405 - 413 .
Greider , C.W. ; Telomerase activity, cell proliferation, and cancer ;
Proc. Natl. Acad. Sci.
USA
, 1998 ,
95
( 1 ), 90 - 92 .
Broccoli , D. ; Young , J.W. ; de Lange , T.; Telomerase activity in normal and malignant
hematopoietic cells;
Proc. Natl. Acad. Sci. USA
, 1995 ,
92
( 20 ), 9082 - 9086 .
Masutomi , K. ; Yu , E.Y. ; Khurts , S. ; Ben - Porath , I. ; Currier , J.L. ; Metz , G.B.
et al.
; Telom-
erase maintains telomere structure in normal human cells;
Cell
, 2003 ,
114
( 2 ), 241 - 253 .
Morin , G.B. , The human telomere terminal transferase enzyme is a ribonucleoprotein
that synthesizes TTAGGG repeats;
Cell
, 1989 ,
59
( 3 ), 521 - 529 .
Stewart , S.A. ; Weinberg , R.A.; Telomeres: cancer to human aging;
Annu. Rev. Cell Dev.
Biol.
, 2006 ,
22
, 531 - 557 .
Bodnar , A.G. ; Ouellette , M. ; Frolkis , M. ; Holt , S.E. ; Chiu , C.P. ; Morin , G.B.
et al.
; Exten-
sion of life-span by introduction of telomerase into normal human cells [see comments];
Science
, 1998 ,
279
( 5349 ), 349 - 352 .
Hanahan , D. ; Weinberg , R.A. ; The hallmarks of cancer ;
Cell
, 2000 ,
100
( 1 ), 57 - 70 .
Mergny , J.L. ; Riou , J.F. ; Mailliet , P. ; Teulade - Fichou , M.P. ; Gilson , E. ; Natural and phar-
macological regulation of telomerase;
Nucleic Acids Res.
, 2002 ,
30
( 4 ), 839 - 865 .
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.