Chemistry Reference
In-Depth Information
DNA could lock the 3
- G - overhang in a G - quadruplex structure that is no longer
recognized by telomerase; this could in turn inhibit replication of telomeres or uncap
telomeres by impeding the binding of telomeric proteins. The latter approach is at
present under investigation in our laboratory. Targeting telomere mechanisms could
be of growing interest for future successful therapeutic anticancer strategies, since
telomeres rather than telomerase may be the universal target for cancer therapy.
′
Acknowledgements
We wish to thank Dr M.P. Teulade-Fichou, Dr D. Monchaud, H. Bertrand and Dr
E. Segal-Bendirdjian for helpful discussions, and the Association pour la Recherche
contre le Cancer (grants 3482 and 4835) for fi nancial help.
Abbreviations
TRF1
Telomere repeat factor 1
TRF2
Telomere repeat factor 2
POT1
Protection of telomere 1
TIN2
TRF1 interacting nuclear protein 2
TPP1
Tripetidylpeptidase 1
Rap1
Repressor/activator protein 1
hTR
Human telomerase RNA component.
hTERT
Human telomerase reverse transcritase
3
′
- G - overhang
Single strand of the 3
′
extremity of telomere that consists of G-rich
repeated sequences
Pt - MPQ
Platinum - quinacridine complex
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