Chemistry Reference
In-Depth Information
Figure 7.6
Chemical formulae of selected metallo-organic G-quadruplex ligands
external G-quartet.
107
Therefore, transition metals are considered very appealing,
thanks to their multiple and controllable geometries, the possible modifi cations of
their coordination environment and their easy synthetic access. Moreover, it has
been highlighted that the metal centre is a key parameter governing the recognition
of G-quadruplex using a family of terpyridine metallo-organic complexes.
108
The
pertinence of this approach has been demonstrated by the high selectivity of saphen
(Ni(II)),
109
terpyridine (Cu(II) and Pt(II)),
108
porphyrins (Mn(III),
110
Cu(II)
111,112
and Ni(II)
113, 114
) and phthalocyanine derivatives (Zn(II) and Ni(II)
115
,
116
) for G-
quadruplexes (Figure 7.6 ).
7.5 Cisplatin
The antitumour effect of the drug cisplatin,
cis
- [Pt(II)Cl
2
(NH
3
)
2
], was discovered in
1965.
117
The cellular target of cisplatin, which triggers its anticancer activity, is
