Chemistry Reference
In-Depth Information
Figure 6.3
Mismatch repair mechanism in mammalian cells
patible, NHEJ almost always repairs the break accurately, with no sequence loss.
25
This mechanism does not have quality control on the basis of sequence homology
and, hence, is not error-free, and can lead to deletions and inversions. Imprecise
repair leading to loss of nucleotides can also occur, but is much less common. Inter-
estingly, cisplatin inhibits repair of double-strand breaks by NHEJ.
26 - 28
