Chemistry Reference
In-Depth Information
view from the major groove
view from the minor groove
platinum
nitrogen
carbonium
oxygen
phosphorus
Figure 5.15
(Plate 9)
Central portion (four base-pairs) of oligonucleotides containing G/G
intrastrand (top) and interstrand (bottom) crosslinks (based on data from Refs 114 and 143,
respectively) (See colour plate section)
crosslinks (intra-CL) the
cis
- A
2
Pt moiety is located in the major groove, and the
six-membered rings of the two guanines are on the same side of the platinum coor-
dination plane (head-to-head, HH, conformation, Figure 5.15). In contrast, when
platinum crosslinked G residues of opposite strands (inter-CL), the
cis
- A
2
Pt moiety
