Platinum Drugs, Nucleotides and DNA : The Role of Interligand Interactions - Metal Complex-DNA Interactions - page 144

platinum hydrogen nitrogen

carbonium oxygen phosphorus

Figure 5.9 (Plate 7) X-ray structures of two cis -A 2 Pt(5 -GMP) 2 adducts showing how in the

D HT conformer (top, based on data from Ref. 117) the 5

′

′ -phosphate is directed towards

the cis amine, while in the -

phosphate is directed towards the cis guanine. For simplicity only the chelate ring atoms of
the carrier ligands (Me 4 dach in the former case and Me 4 en in the latter case) are shown
(See colour plate section)

Λ HT conformer (bottom, based on data from Ref. 118) the 5 ′