Biomedical Engineering Reference
In-Depth Information
renewal and pluripotency. ES and iPS cell differentiation into multiple
cell lineages is partially dependent on the processes of embryonic
development. On the basis of developmental studies, methods
for cardiac cell induction from stem cells have been developed by
using several molecules related to signaling pathways. Although the
effects of several molecules on cardiac differentiation have been
reportedandinductionefficiencyimproved,thereisadifference
between the differentiation abilities of various cell lines and culture
systems.Fromthisviewpoint,inadditiontodevelopingefficient
and universal methods for cardiac differentiation, development of
large-scale culture systems and methods of selecting differentiated
cardiac cells is still required.
References
1. Evans, M.J., Kaufman, M.H. (1981). Establishment in culture of
pluripotential cells from mouse embryos,
, pp. 154-156.
2. Thomson,J.A.,Itskovitz-Eldor,J.,Shapiro,S.S.,Waknitz,M.A.,Swiergiel,
J.J.,Marshall,V.S.,Jones,J.M.(1998).Embryonicstemcelllinesderived
from human blastocysts,
Nature
,
292
, pp. 1145-1147.
3. Takahashi, K., Yamanaka, S. (2006). Induction of pluripotent stem
cellsfrommouseembryonicandadultfibroblastculturesbydefined
factors,
Science
,
282
Cell
,
126
, pp. 663-676.
4. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda,
K., Yamanaka, S. (2007). Induction of pluripotent stem cells from adult
humanfibroblastsbydefinedfactors,
, pp. 861-872.
5. Parameswaran, M., Tam, P.P. (1995). Regionalisation of cell fate
and morphogenetic movement of the mesoderm during mouse
gastrulation,
Cell
,
131
, pp. 16-28.
6. DeRuiter, M.C., Poelmann, R.E., VanderPlas-de Vries, I., Mentink,
M.M.,Gittenberger-deGroot,A.C.(1992).Thedevelopmentofthe
myocardium and endocardium in mouse embryos. Fusion of two heart
tubes?
Dev. Genet.
,
17
, pp. 461-473.
7. Antin,P.B.,Taylor,R.G.,Yatskievych,T.(1994).Precardiacmesodermis
specifiedduringgastrulationinquail,
Anat. Embryol. (Berl.)
,
185
, pp. 144-154.
8. Montgomery,M.O.,Litvin,J.,Gonzalez-Sanchez,A.,Bader,D.(1994).
Staging of commitment and differentiation of avian cardiac myocytes,
Dev. Biol.
Dev. Dyn.
,
200
,
164
, pp. 63-71.
