Biomedical Engineering Reference
In-Depth Information
Table 2a.1
Key molecules for paracrine effects in cell transplantation to the injured heart
Cardioprotection
Angiogenesis
Stem cell migration Anti-inflammation Contractility
ECM reconstruction
sFRP1, 2
VEGF
SDF-1
IL-6
GH
Thymosin
b
4
Thymosin
b
4
HGF
VEGF
IL-11
IGF-1
FGF-2
HGF
FGF-2
FGF-2
MMP1, 2, 9
IGF-1
Angiopoietin-1
MCP-1
TIMP1, 2
LIF
TGF
b
1
SCF
CTGF
sVCAM-1
IL-1
b
, IL-6
sVCAM-1
Angiogenin
PDGF-A
sVCAM-1
Abbreviations
: sFRP, secreted frizzled-related protein; HGF, hepatocyte growth factor; IGF, insulin-like growth factor; LIF, leukemia inhibitory factor;
sVCAM, soluble vascular cell adhesion molecule; VEGF, vascular endothelial growth factor; FGF, fibroblast growth factor; TGF, transforming growth
factor; IL, interleukin; PDGF, platelet-derived growth factor; SDF, stromal cell-derived factor; MCP, monocyte chemotactic protein; SCF, stem cell factor;
GH, growth hormone; ECM, extracellular matrix; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinases; CTGF, connective tissue
growth factor.
