Biomedical Engineering Reference
In-Depth Information
Chapter 6b
Cell Sheet-Based Myocardial Tissue
Engineering
Yuji Haraguchi and Tatsuya Shimizu
Institute of Advanced Biomedical Engineering and Science,
Tokyo Women's Medical University, 8-1 Kawada-cho,
Shinjuku-ku, Tokyo, 162-8666, Japan
yharaguchi@abmes.twmu.ac.jp
6b.1 Introduction
Cardiovascular disease (CVD) is one of the major causes of morbidity
and mortality and a major medical problem in the world [1]. Cell-
based regenerative medicine has an attractive potential as a therapy
for CVD, and clinical trials using autologous cell injection have been
performed [2-6]. However, cell death and cell loss after cell injection
are the major problems of dissociated cell injection therapy and
may hinder its effective efficacy strongly [7, 8]. Tissue engineering
has been progressing rapidly for finding an alternative to the
direct injection of dissociated cells. The transplantation of three-
dimensional (3D) bioengineered tissues using beating cardiac cells
or autologous cells has shown a good therapeutic effect in various
