Biomedical Engineering Reference
In-Depth Information
has human microvessels that are perfused by the host coronary
circulation.
6a.5 Conclusion
Pulsatile myocardial tissue can be reconstructed by seeding cardiac
cells into scaffolds, hydrogel, or decellularized native tissues in
vitro, and the reconstructed tissue can be easily transplanted into
host tissues. After being transplanted onto a damaged myocardium
in animal models, the implanted graft couples electrically to the
host heart, survives for a long term in the host, and shows good
therapeutic effects. In addition, the therapeutic effects of pulsatile
myocardial tissue are found to be higher than those of nonpulsatile
tissue. The reconstruction of macroscopically pulsatile heart-like
tissue, human myocardial tissue, and vascularized myocardial tissue
has been reported. Several research studies using human ESC-/iPSC-
derived cardiomyocytes have also been started. Tissue engineering
should have an enormous potential for reconstructing in vitro
3D myocardial tissue models and for contributing to myocardial
regenerative medicine.
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