Biomedical Engineering Reference
In-Depth Information
Chapter 6a
Scaffold-Based Myocardial Tissue
Engineering
Yuji Haraguchi and Waki Sekine
Institute of Advanced Biomedical Engineering and Science,
Tokyo Women's Medical University, 8-1 Kawada-cho,
Shinjuku-ku, Tokyo, 162-8666, Japan
yharaguchi@abmes.twmu.ac.jp
6a.1 Introduction
Cell-based regenerative medicine is a new hope as a promising
therapy for cardiovascular disease (CVD), and various clinical trials
using autologous cell injections have been performed [1-4]. More
recently, scaffold-based and cell sheet-based tissue engineering
methodologies have appeared as the next generation of cell therapy for
CVD, and clinical trials using the technology have already performed
[1, 5-10]. The transplantation of engineered three-dimensional (3D)
tissue reconstructed by using autologous stem/progenitor cells has
been shown to have higher therapy efficacy than direct cell injection
therapy in animal models and a clinical trial [11-13]. On the other
hand, most autologous adult stem/progenitor cells can hardly
