Biomedical Engineering Reference
In-Depth Information
9.8 Formal Development of the Two-Electrode Cardiac
Pacemaker
9.8.1 Context and Abstract Model
In this section, we describe the formal development of initial modes of the two-
electrode pacemaker system using the basic notion of action-reaction and real-time
constraints, to focus on pacing and sensing activities of the pacemaker's actuator
and sensor. The initial context of the two-electrode pacemaker is similar to the one-
electrode pacemaker. We give here only newly defined constants and axioms. A new
constant atrioventricular (AV) interval (FixedAV) is defined in
axm
8. Refractory pe-
riod constants Atria Refractory Period (ARP), Ventricular Refractory Period (VRP)
and Post Ventricular Atria Refractory Period (PVARP) are defined by axioms (
axm
9,
axm
10 and
axm
11). Another new constant
V
_
Blank
is defined as blanking period
as an initial period of VRP. Finally, we introduce some basic initial properties using
defined constants of the system by axioms (
axm
13,
axm
14 and
axm
15).
axm
8
:
FixedAV
∈
70
..
300
axm
9
:
ARP
∈
150
..
500
axm
10
:
VRP
∈
150
..
500
axm
11
:
PVARP
∈
150
..
500
axm
12
30
..
60
axm
13
:
URI > PVARP
axm
14
:
URI > VRP
axm
15
:
VRP
≥
PVARP
:
V
_
Blank
∈
Abstraction of DDD Mode
In the two-electrode pacemaker system, the pacemaker delivers a pacing stimulus
in both atrial and ventricular chambers. In DDD operating mode, the first letter 'D'
represents that the pacemaker paces in both atrial and ventricle chambers; second
letter 'D' represents that the pacemaker senses intrinsic activities from both atrial
and ventricle chambers and final letter 'D' represents two conditional meaning that
depends on atrial and ventricular sensing; first is that atrial sensing inhibits atrial
pacing and triggers ventricular pacing and second is that ventricular sensing inhibits
ventricular and atrial pacing [
22
,
35
].
Two new variables
PM_Actuator_A
and
PM_Actuator_V
are defined that repre-
sent ON or OFF state of the pacemaker's actuators for pacing in both atrial and ven-
tricular chambers. Similarly next two variables
PM_Sensor_A
and
PM_Sensor_V
represent ON or OFF state of the pacemaker's sensor for sensing an intrinsic pulse
from both atrial and ventricular chambers. An interval between two paces is de-
fined by a new variable
Pace_Int
that must be between upper rate interval (URI)
and lower rate interval (LRI), is represented by an invariant (
inv
5). A variable
sp
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