Biomedical Engineering Reference
In-Depth Information
Figure 10-10. Delamination trajectory for a fixed adhesion energy but with a range of
magnitude and range of surface forces.
to deduce the intersurface force range and magnitude. Further
complications due to non-zero flexural rigidity, tensile pre-stress, large
deformations due to rubber elasticity, and viscoelasticity can be
incorporated into the model, but are beyond the scope of this chapter.
5.
Conclusions and Outlook
Various modes of nanoindentation have been extensively applied for
mechanically characterizing biological cells and membranes. Non-
invasive, in-situ and experimentalist-friendly indentation methods are
important for the instrumental developments. Multiscale linear elastic
models for indentation, bending and stretching mechanical stresses for
small to large deformation for data analysis are presented. Nonlinear
large deformation models are highly desirable for analyzing the force-
displacement relation of most biological materials.
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