NANOINDENTATION OF SOFT TISSUES AND OTHER BIOLOGICAL MATERIALS - Nanoindentation with Biological Applications - page 281

Table 9-1. Summary of nanoindentation studies of articular cartilage.

Study Purpose of Study Animal Model Tip Geometry Mechanical Measures

Ebenstein
et al. 2004 18

Compare mechanical properties of
repair and control cartilage;
Correlate mechanics with histology

rabbit knee 100 m radius of curvature

sphere

μ Functional parameters

(contact stiffness, resistance
to penetration (~hardness),
and volumetric creep rate)

Franke et al.
2007 19

Compare mechanical properties of
repair and control cartilage;
Correlate mechanics with histology;
Compare effects of storage fluids;
Investigate depth dependence of
mechanical properties

miniature pig knee Berkovich (3-sided pyramidal)

tip

Contact stiffness, reduced
modulus, and hardness

Li et al .
2006 20

Compare mechanical properties of
cartilage in different regions of joint;
Correlate mechanics with
morphological measures

rabbit metacarpo-
phalangeal (finger)
joint

100 m radius of curvature

sphere

μ Functional parameters

(contact stiffness, resistance
to penetration (~hardness),
and volumetric creep rate)

Simha et al.
2004 21

Measure fracture toughness Bovine patella 10 μm end diameter flat-ended

cone (67° included angle)

Fracture toughness

Simha et al .
2007 22

Determine effect of indenter size on
mechanical properties

Bovine patella 5 μm to 4 mm end diameter

flat-ended cone (60° included
angle) and cylindrical tips

Equilibrium elastic
modulus