Biology Reference
In-Depth Information
Provided with rich information about biochemical reactions and gene regulation, availability of var-
ious biological databases, building an integrative model of the whole cell (virtual cell modelling) that
incorporates gene regulation, metabolic reactions and signal transductions is becoming a promising field
in the post-genomic era. Several projects have been established. The challenge created with Petri nets
is to understand how all the cellular proteins work collectively as a living system. Using powerful Petri
nets and computer techniques, data of metabolic pathways, gene regulatory networks and signalling
pathways could be converted for Petri net applications. Thus, a Petri net based virtual cell model could
be implemented, and the attempt to understand the logic of the cell could be accomplished.
ACKNOWLEDGEMENTS
The work was partly supported by the Ministry of Science and Art of the Government of Sachsen-
Anhalt, and by the German Research Foundation (DFG) graduate program “Bioinformatics” in the
Uni-Bielefeld.
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