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Fig. 5. PN module for enhanced protein-protein interaction. The presence of enhancer proteins stabilizes complex formation
and results in an increased output of dimer,
AB
, compared to dimerization without the influence of enhancer protein,
E
. Note
that in contrast to Fig. 3, enhancer
E
only mediates a temporary effect until the dimer,
AB
, has stabilized its interaction. (a)
The module with a dissociation transition for dimer,
AB
(dashed line), which results in four T-invariants, including one with an
arc weight of two, which corresponds to a higher output of
AB
(blue pathway), and one producing
AB
via a possibly undirected
self-stabilized interaction (red pathway). Enhancer is regenerated (dashed line). (b) Replacement of the dissociation reaction by
an output transition (red pathway) reduces the number of T-invariants, while preserving the essential model function of enhancer
dependent complex formation. (Colours are visible in the online version of the article at
www.iospress.nl
.)
the PN, the hydrolyzation activity could not be modeled, because of the lack of kinetic parameters.
Finally, since several DExD/H box proteins are involved in spliceosome assembly, the total accuracy
of splicing may depend on the cumulative success of enzyme modulated signal transduction along
the pathway, further complicating the corresponding kinetic model.
