Biology Reference
In-Depth Information
Fig. 12. An HFPN representation of autocatalytic process in Fig. 10.
Fig. 13. Simulated time courses of some intermediates during apoptosis for the Fas ligand concentration
n
=
210, 450, 600.
add other pathways through Bcl-2 family or p53 to describe the real apoptosis occurring in various cells
and by various inducers.
CONCLUSIONS
The effectiveness of HFPN based biopathway modeling is demonstrated by two examples, the circadian
rhythm in
Drosophila
and the apoptosis induced by Fas ligand. Simulations of these models are performed
with the software tool
Genomic Object Net
and some observations in biological aspects are obtained.
We have developed
Genomic Object Net
Visualizer (GON Visualizer) based on XML technology [22].
GON Visualizer allows us to visualize simulation results of GON, which are exported as CSV files. With
this tool users in biology/medicine can perform visualizations of simulation results of the aimed biological
phenomenon by creating XML documents in which CSV files produced from GON are included as basic
