Chemistry Reference
In-Depth Information
O
NH
O
O
O
Pd
2
(dba)
3
.CHCl
3
,
BINAP, KO
t
-Bu
N
NaHCO
3
2.488
O
O
+
Br
OMe
ClOC
OMe
O
2.490
OMe
Br
OMe
2.489
O
O
O
1. NaBH
4
2. Et
3
SiH, BF
3
.OEt
3
O
N
N
O
O
O
OMe
OMe
2.492
OMe
2.491
OMe
Scheme 2.140
Br
CO
2
Et
(Ph
3
P)
4
Ni
+
BrZn
CO
2
Et
MeO
MeO
2.493
2.495
2.494
Scheme 2.141
OMe
O
O
Ph
MeO
N
Me
PhBr, NaOt-Bu,
Ni(COD)
2
, L
Me
N
L =
MeO
OMe
PPh
2
Ph
2
P
2.496
2.497
92% e.e.
2.498
Scheme 2.142
2-Naph
OTf
OSiMe
3
(TMEDA)PdMe
2
,
LiOAc, L
+
CO
2
Me
O
PCy
2
O
t
-Bu
L =
CO
2
Me
S
S
Me
CO
2
Me
2.499
2.500
2.501
96% e.e.
2.502
Scheme 2.143
OH
OH
Pd(OAc)
2
, (
o
-tol)
3
P,
Cs
2
CO
3
I
O
O
2.503
2.504
Scheme 2.144
