Biomedical Engineering Reference
In-Depth Information
Table 6.2
Long-term (> 20 weeks) studies of induced regeneration of peripheral nerves in exper-
imental animals. Electrophysiological data. (Expressed as fraction of normal value (fidelity of
regeneration))
Experimental parameters
Electrophysiological properties
(fraction of normal value)
Animal model
(length of
study, weeks)
Gap
length,
mm
Tube
Tube
filling
Latency Conduction
velocity
Ampli-
tude
References
Sciatic, rat
(43)
10
Silicone None
(1)
0.64
0.09
Fields and
Ellisman
1986a; Fields
et al. 1989
Sciatic, rat
(40)
10
Silicone NRT
a
:
5 μm
pores
10 μm
60 μm
300 μm
1.38
1.39
1.51
1.64
0.59
0.63
0.57
0.54
0.22
0.55
0.42
0.20
Chang et al.
1990; Chang
and Yannas
1992
Sciatic, rat
(60)
10
Silicone NRT
a
:
35 μm
0.48
0.27
Chamberlain
et al. 1998b
Sciatic, mouse
(21.4)
6
Silicone None
0.07
Navarro et al.
1996
Sciatic, mouse
(21.4)
6
PTFE
b
None
0.02
Navarro et al.
1996
Rabbit, tibial
(36)
10
PGL
c
None
(1)
Molander
et al. 1983
Monkey,
median (52)
< 1
PGA
d
None
0.94
0.32
Tountas et al.
1993
Mouse, sciatic
(21.4)
6
PLLA/
PCL
e
None
0.18
Navarro et al.
1996
Monkey,
median (200)
5
Collagen None
1.40
0.93
0.91
Archibald
et al. 1995
Rat, sciatic
(60)
10
Collagen None
0.60
0.27
Chamberlain
et al. 1998b
Rat, sciatic
(60)
10
Collagen NRT:
35 μm
pores
0.75
0.36
Chamberlain
et al. 1998b
Mouse, sciatic
(21.4)
6
collagen None
0.07
Navarro et al.
1996
Cat, sciatic
(69)
25
PGA
d
mesh/
collagen
NGF/
bFGF/
laminin
1.7
(ca. 1)
Kiyotani et al.
1996
< 1
a
NRT
nerve regeneration template, a graft copolymer of type I collagen and chondroitin
6-sulfate, similar in structure to dermis regeneration template (
DRT
). It was originally studied
as a filling for silicone tubes (e.g., Yannas et al. 1985, 1987a, c, 1988, 1991; Chang and Yannas
1990; Chang and Yannas 1992). After about 2000, tubes fabricated from a version of NRT that
omitted chondroitin 6-sulfate were generally used (Chamberlain et al. 2000a; Soller et al. 2013)
b
PTFE
poly(tetrafluoroethylene)
c
PGL
polyglactin 910
d
PGA
poly(glycolic acid)
e
LA/e-PCL
copolymer of lactic acid and ε-caprolactone
