Biomedical Engineering Reference
In-Depth Information
Table 5.3
(continued)
Animal
model (day
observed)
Reactant
C
a
S
a
R
a
References
D. Dermis regeneration template (DRT) (cell-free)
Guinea pig
(Hartley; 300
days)
DRT
0
(12)
Yannas 1981;
Yannas et al.
1981, 1982a, b
88 ± 4
Guinea pig
(Hartley; 50
days)
DRT
92 ± 5
NA
c
NA
c
Yannas et al.
1989
Guinea pig
(Hartley; 21
days)
DRT
(0)
Orgill et al.
1996
(> 51 ± 14)
(< 49 ± 14)
Guinea pig,
island graft
(Hartley; 14
days)
DRT
No contrac-
tion of grafted
island
0
Dermis simi-
lar to that
with fitted
DRT grafts
Orgill and Yan-
nas 1998
Swine (York-
shire pig; 21
days)
DRT
0
Orgill et al.
1996; Butler
et al. 1998,
1999a
9 ± 7
91 ± 7
E. Keratinocyte-seeded DRT
Guinea pig
(Hartley; 300
days)
DRT seeded
with uncul-
tured KC
0
Yannas et al.
1981, 1982a, b,
1984, 1989a;
Orgill 1983;
Murphy et al.
1990
28 ± 5
72 ± 5
Athymic
mouse (270
days)
DRT cultured
with FB
d
and
KC
Minimal scar Dermis
formed
Cooper and
Hansbrough
1991
77.5 ± 0.9 (42
days)
Athymic
mouse (42
days)
DRT cultured
with FB
d
and
KC
Minimal
contraction
NA
c
NA
c
Cooper et al.
1993
Guinea pig,
island graft
(Hartley; 22
days)
DRT seeded
with uncul-
tured KC
No contrac-
tion of island
graft
0
Dermis
formed
Orgill and Yan-
nas 1998
Swine (York-
shire pig; 35
days)
DRT seeded
with uncul-
tured KC
NA
c
NA
c
Dermis
formed
Compton et al.
1998
F. Synthetic polymeric mesh (PGL 910) seeded with keratinocytes and fibroblasts
(
Living
dermal replacement, LDR
)
Athymic
mouse (20
days)
Polyglac-
tin-910 mesh
cultured with
FB
d
(KC
omitted)
Marked
contraction
NA
c
NA
c
Hansbrough
et al. 1993
Athymic
mouse (20
days)
Polyglac-
tin-910 mesh
cultured with
Minimal
contraction
No rete ridges Dermis?
Cooper et al.
1991; Hans-
brough et al.
